Published in Cancer Weekly, August 5th, 1996
Innovative cancer therapies over the past few years have progressed to include genetic manipulation. Approaches have included the delivery of cytotoxic genes, such as the herpes simplex-thymidine kinase suicide gene; the delivery of tumor suppressor genes; and the delivery of immunostimulatory cytokine genes. Unfortunately, a limiting factor of cytotoxic suicide gene delivery and tumor suppressor gene delivery is the need to infect almost every single tumor cell by either/or a combination of direct gene transfer and bystander effect in...
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