Published in Cancer Weekly, August 12th, 1996
An important goal of gene therapy research is facilitated by the efficient introduction of foreign DNA into heart cells for research purposes. Because there are no stable cardiac myocyte cell lines, research has been restricted to transient transfections. The standard transfection methods, which include calcium phosphate precipitation, cationic lipid/plasmid DNA complexes, and incubations with 'naked' plasmid DNA, achieve very low transfection efficiencies in cardiac cells, generally no more than a few percent.
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