"Induction of the Death-Promoting Gene bax-alpha Sensitizes Cultured Breast-Cancer Cells to Drug-Induced Apoptosis."

According to the authors' abstract of an article published in International Journal of Cancer, "Resistance to apoptosis plays an important role in malignancies that are refractory to chemotherapy treatment. Recently we have shown that the expression of bax-alpha, a death-promoting member of the bcl-2 family, is down-regulated in breast cancer and have provided evidence that low box expression might contribute to the pathogenesis of breast cancer. In this study we were able to demonstrate the role of this gene in chemotherapy-induced apoptosis. We transfected bax-alpha into the breast-cancer cell lines R30C and MCF-7 under the control of an inducible tetracycline-dependent expression...

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