Prostate Cancer
"Induction of Apoptosis by Diethylstilbestrol in Hormone-Insensitive Prostate Cancer Cells."
Published in Cancer Weekly, August 12th, 1996
According to the authors' abstract of an article published in Journal of the National Cancer Institute, "Background: Diethylstilbestrol (DES) and diethylstilbestrol diphosphate (DESdP) are effective agents for the treatment of advanced prostate cancers. Tumor-inhibiting effects of DES and DESdP are presumed secondary to suppression of androgen production in vivo. Little is known, however, about the direct cellular mechanisms of the tumor inhibition. Estrogens have been reported not only to stimulate growth but also to disrupt microtubule formation in prostate cancer cells, Purpose: The study was designed to examine and compare mechanisms of in vitro growth inhibition...
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Source: Cancer Weekly (1996-08-12)
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