"Modulation of Receptor Activity and Cell Cycling Independently Regulate Retroviral Gene Transfer."

According to an abstract submitted by the authors at the annual meeting for the Association of American Physicians, American Society for Clinical Investigation, and American Federation for Clinical Research, entitled Biomedicine '96: Medical Research from Bench to Bedside, held May 3-6, 1996, in Washington DC, "Retroviral receptor expression in hepatocytes is upregulated during liver regeneration, although whether increased receptor expression could by itself improve hepatic gene transfer is unknown. To dissect mechanisms in retroviral gene transfer, we used an in vitro system based upon human Huh-7.MCAT-1.7 cells, which constitutively express the murine ecotropic retroviral receptor,...

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