Conference Coverage (Vancouver AIDS Conference)
Immunotoxin Knocks Out KS
Published in Cancer Weekly, August 26th, 1996
Researchers have found that KS cells express extremely high levels of the interleukin 13 (IL-13) receptor.
Taking advantage of this finding, they created an immunotoxin that combines IL-13 with the cytopathic moiety of Pseudomonas endotoxin. This toxin selectively kills KS cells in vitro.
"IL-13 receptors on AIDS-KS tumors represent a novel plasma membrane protein for targeting with a potent cytotoxic agent such as Pseudomonas toxin-based chimeric protein," said Syed R. Husain of the U.S. Food and Drug Administration (FDA) Center for Biologics...
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Source: Cancer Weekly (1996-08-26)
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