Vaccine Development
"Effects of Immunization Against GnRH in Animals and Prostate Cancer Patients."
Published in Cancer Weekly, August 26th, 1996
According to an abstract submitted by the authors to the 10th International Congress of Endocrinology, sponsored by the International Society of Endocrinology and the Endocrinology Society, held June 12-15, 1996, in San Francisco, California, "One approach in the development of male contraceptives is to suppress spermatogenesis through active immunization against gonadotropin releasing hormone (GnRH). A gonadotropin releasing hormone-tetanus toxoid conjugate (GnRH-TT) was prepared by reacting (Gln1)-GnRH with tetanus toxoid in the presence of water soluble carbodiimide. Immunization of rats with three injections of 100 (mu)g of GnRH-TT at weeks 0, 4 and 8 suppressed their...
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Source: Cancer Weekly (1996-08-26)
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