"Malignant Melanoma: Relationship of the Human Leukocyte Antigen Class II Gene DQB1*0301 to Disease Recurrence in American Joint Committee on Cancer Stage I or II."

According to the authors' abstract of an article published in Cancer, "Background: Melanoma patients who carry the human leukocyte antigen (HLA) Class II allele DQB1*0301 have an increased frequency of metastases at presentation compared with those lacking HLA-DQB1*0301. This study was designed to determine whether HLA-DQB1*0301 is associated with an increased risk of recurrence in melanoma patients presenting with American Joint Committee on Cancer (AJCC) Stage I or II (localized) disease. Methods: Molecular oligotyping of HLA-DQ genes was performed for 259 patients with AJCC Stage I or II melanoma. Rate of disease recurrence was determined by retrospective review and...

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