"Dendritic Cells Pulsed with RNA Are Potent Antigen-Presenting Cells in vitro and in vivo."

According to the authors' abstract of an article published in Journal of Experimental Medicine, "Immunization with defined tumor antigens is currently limited to a small number of cancers where candidates for tumor rejection antigens have been identified. In this study we investigated whether pulsing dendritic cells (DC) with tumor-derived RNA is an effective way to induce CTL and tumor immunity. DC pulsed with in vitro synthesized chicken ovalbumin (OVA) RNA were more effective than RNA peptide-pulsed DC in stimulating primary, OVA-specific CTL responses in vitro. DC pulsed with unfractionated RNA (total or polyA⁺) from OVA-expressing tumor cells were as effective as DC...

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