Published in Cancer Weekly, November 18th, 1996
Several gene therapy modalities for treating cancer revolve around the use of DNA constructs to replace or modify defective genes or to introduce genes encoding cytotoxic proteins or immunomodulates. Chimeric constructs composed of radiation-inducible promoters linked to therapeutic genes encoding cytotoxic proteins suggest clinical potential because ionizing radiation can be used to both activate and regulate gene expression.
In earlier research, Ralph R. Weichselbaum and colleagues from the University of Chicago,...
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