"Spontaneous Apoptosis in Gallbladder Carcinoma: Relationships with Clinicopathologic Factors, Expression of E-cadherin, bcl-2 Protooncogene, and p53 Oncosuppressor Gene."

According to the authors' abstract of an article published in Cancer, "Background: Although valuable information regarding spontaneous apoptosis in various human cancers has recently been obtained, spontaneous apoptosis in carcinoma of the gallbladder has not been studied. Methods: Apoptotic cells were visualized using the nick end labeling method in 49 cases of gallbladder carcinoma. The relationships between frequency of apoptosis, which was expressed as the maximal apoptotic index (MAI), and clinicopathologic factors, immunoreactivity of E-cadherin (E-CD), bcl-2 protooncogene, and p53 oncosuppressor gene were investigated. Results: MAI was significantly...

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