"Regression of a Human Breast Cancer is Accompanied by Down Regulation of p53 Following Treatment with an AAV Vector Containing the Consensus IFN-Gene."

According to an abstract submitted by the authors to the First Joint Meeting of the International Cytokine Society and the International Society for Interferon and Cytokine Research, held October 6-10, 1996, in Geneva, Switzerland, "Xenografts of the human breast cancer cell line, MDA-MB-435 when transplanted into 4-6 week old female mice, result in tumor formation. Treatment of established tumors with AAV vectors containing the IFN-con1 gene directly into the tumor mass at three day intervals resulted in significant decrease in growth rate. Tumors treated with 100,000 units of IFN-con1 or MV-neo at similar intervals did not inhibit tumor growth. Immuno-histochemical analysis of excised...

Want to see the full article?

• Purchase this article for only $3.00