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Drug Development

"Plant-Derived Anticancer Agents."

Published in Cancer Weekly, February 3rd, 1997

According to the author's abstract of an article published in Biochemical Pharmacology, "Natural product drugs play a dominant role in pharmaceutical care. This is especially obvious in the case of antitumor drugs, as exemplified by paclitaxel (Taxol(R)), vincristine (Oncovin(R)), vinorelbine (Navelbine(R)), teniposide (Vumon(R)), and various water-soluble analogs of camptothecin (e.g., Hycamtin(R)). The most efficient method of discovering drugs such as these (i.e. novel chemical prototypes that may function through unique mechanisms of action) is bioactivity-guided fractionation, and it is certain that additional natural product drugs, some of which should be useful for the treatment...

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