Cancer Vaccines
"A Plasmid DNA Anti-Idiotype Tumor Vaccine against B-Cell Lymphoma."
Published in Cancer Weekly, February 3rd, 1997
According to an abstract submitted by the authors to the Fifth International Conference on Gene Therapy of Cancer, held November 14-16, 1996, in San Diego, California, "Anti-tumor vaccines have been proposed as a possible alternative to post-surgical chemotherapy for treating metastatic cells expressing a tumor-specific antigen. Non-Hodgkin's B-Cell lymphoma fulfills this criteria in that metastases result from a clonal line of cells expressing a single idiotype immunoglobulin antigen. To develop a DNA vaccine approach for the treatment of such lymphomas, we constructed a bicistronic plasmid DNA (VR1605) which enables easy cloning and high level expression of tumor specific idiotype...
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Source: Cancer Weekly (1997-02-03)
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