Transplantation (Bone Marrow)

Drug Combination Shows Promise as GVHD Prophylaxis Regimen

Published in Cancer Weekly, February 3rd, 1997

Tacrolimus combined with minidose methotrexate is safe, and the combination may be effective in preventing acute graft-versus-host disease (GVHD) in recipients of bone marrow from unrelated donors.

To assess the combination of tacrolimus combined with a reduced dose schedule of methotrexate to prevent acute GVHD, Donna Przepiorka, M.D., Ph.D., the University of Texas M.D. Anderson Cancer Center, Houston, Texas, and colleagues studied 30 adults with leukemia or lymphoma undergoing marrow transplantation from HLA-compatible unrelated donors ("Tacrolimus and Minidose Methotrexate for Prevention of Acute Graft-Versus-Host Disease after Matched Unrelated Donor Marrow...

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Source: Cancer Weekly (1997-02-03)

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