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Hepatocellular Carcinoma (Pathogenesis)

"Chronic Viral Hepatitis Induced by Hepatitis C But Not Hepatitis B Virus Infection Correlates with Increased Liver Angiogenesis."

Published in Cancer Weekly, February 17th, 1997

According to the authors' abstract of an article published in Hepatology, "Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections lead to cirrhosis and increase the risk for the development of hepatocellular carcinoma (HCC). Angiogenesis is an essential step in oncogenesis and contributes to tumor progression in adult organs; however, to what extent angiogenesis occurs in the liver during chronic viral hepatitis has not been studied. Ninety-nine matched patients affected by chronic hepatitis due to either HBV or HCV were studied together with 13 controls (5 patients were affected by familial hyperbilirubinemia with normal liver histology; 6 patients with stage II primary...

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