Cancer Gene Therapy

Targeting of Melanoma Cells Possible with Recombinant Adenoviruses

Published in Cancer Weekly, February 17th, 1997

A National Cancer Institute study determined that transcriptional regulatory elements help high-titer recombinant adenovirus vectors specifically target human melanoma cells in vitro.

Potential avenues for gene therapy include the specific targeting of effector genes to cancer cells, including distant metastatic sites. As a first step toward this goal, William M. Siders and colleagues from the U.S. National Cancer Institute-Frederick Cancer Research and Development Center tested the ability of the transcriptional regulatory elements of the mouse and human tyrosinase genes to promote high levels of pigment cell-specific transcription ("Transcriptional Targeting of...

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Source: Cancer Weekly (1997-02-17)

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