"B7-Negative Versus B7-Positive P815 Tumor - Differential Requirements for Priming of an Antitumor Immune Response in Lymph Nodes."

According to the authors' abstract of an article published in Journal of Immunology, "Efficient T-cell activation requires two synergistic but distinct signals derived from antigenic peptides presented by the MHC and from costimulatory molecules, particularly those belonging to the B7 family. Lack of B7-CD28 interaction may cause unresponsiveness of T cells to subsequent exposure to Ag. Nevertheless, immunization by some B7^- tumors induces an antitumor immune response. We found that the immune response against two B7^- tumors, the mouse P815 mastocytoma and the E7C3 melanoma, requires host-derived B7, since blockage of the B7-CD28 interaction facilitates tumor...

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