Cancer Gene Therapy

Cancer Induced Cachexia Prevented by IL-10 Gene Transfer

Published in Cancer Weekly, March 3rd, 1997

Interleukin 10 (IL-10) gene transfer into Colon 26 cachexia-inducing adenocarcinoma cells prevented the occurrence of cachexia in a murine model.

Cachexia is characterized by progressive weight loss, anemia, and asthenia. It is an intractable condition found in cancer patients that cannot be reduced simply by compensation for negative caloric balance through increased caloric intake.

Unfortunately, patients with cachexia have a poorer prognosis due to a reduced chemotherapeutic response. An effective treatment modality against cachexia could improve cancer patients' response to chemotherapy, their overall prognosis, as well as their quality of...

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Source: Cancer Weekly (1997-03-03)

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