"Targeting Immunotherapy using the Avidin-Biotin System for a Human Colon Adenocarcinoma in vitro."

According to the authors' abstract of an article published in Journal of International Medical Research, "A new method of targeting immunotherapy using the avidin-biotin system in vitro was investigated. Both an anticarcinoembryonic antigen monoclonal antibody (anti-CEA MAb) and an anti-cancer drug, neocarzinostatin (NCS), were biotinylated. A human colon adenocarcinoma cell line (LoVo) was immunized with biotinylated anti-CEA MAb; avidin was added, and the cell line was incubated with various concentrations of biotinylated NCS for either 72 h or 7 min. In the incubation for 72 h, the IC₅₀ was similar (approximate to 0.45 (mu)g/ml) for biotinylated NCS for LoVo cells...

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