AIDS Therapies (Protease Inhibitors)

Protein Pump Prevents Saquinavir Absorption

Published in Cancer Weekly, March 24th, 1997

Researchers from Stanford University, California, have shown that one of the first lines of defense - a versatile pump in the lining of the gut, called P-glycoprotein - may prevent the absorption of saquinavir, one of a generation of anti-HIV drugs.

Saquinavir belongs to a class of drugs known as protease inhibitors.

In 1995, it became the first HIV protease inhibitor to gain approval by the U.S. Food and Drug Administration (FDA). Patients and doctors have found, however, that getting enough saquinavir out of the digestive system to reach HIV infected T cells in the bloodstream is a difficult task.

There are many reasons why...

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Source: Cancer Weekly (1997-03-24)

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