Cancer Gene Therapy

Tumor Transfection with Nitric Oxide Gene Exhibits Bystander Effect

Published in Cancer Weekly, April 14th, 1997

Tumor cells transfected with the inducible nitric oxide synthase (iNOS) gene exhibit destruction of bystander tumor cells.

A causal relationship between production of endogenous nitric oxide (NO) and cell survival has been shown in previous research. Activation of iNOS has been shown to result in the production of high levels of NO, which is then associated with a cytotoxic reaction against pathogens and tumor cells. Several studies have shown that regression of tumors and metastases can be induced by the transfection of iNOS into tumor cells.

Up to this point, however, it has not been known whether every tumor cell must be transfected with the...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Cancer Weekly

Source: Cancer Weekly (1997-04-14)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry