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Supramolecular Cationic Liposome Assemblies Explored

Published in Cancer Weekly, April 21st, 1997

Multivalent cationic liposomes are the next generation of nonviral gene transfer vehicles.

Speaking at an educational symposium at the American Association for Cancer Researchers Conference, held April 12-16, 1997, in San Diego, California, Leaf Huang of the University of Pittsburgh, Pittsburgh, Pennsylvania, expounded on the ongoing development of liposomes as gene delivery vectors.

He remarked that the advantages of liposomes include their simplicity, that they are non-mutagenic, non-immunogenic, easy to prepare, and can handle relatively large DNAs. The disadvantages, which include their sensitivity to serum and propensity to cause aggregation,...

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