Cancer Weekly
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Cancer Gene Therapy
"In vivo Gene Therapy of Murine Melanoma Mediated by Recombinant Vaccinia Virus Encoding Human IL-2 Gene."
May 26th, 1997
According to the authors' abstract of an article published in International Journal of Oncology, "Direct gene transfer into somatic tissue in vivo is a developing technology with potential application for cancer gene therapy. In this study, recombinant vaccinia virus encoding human IL-2 gene (rVV-IL-2) was used as a candidate vector in mediating in vivo gene therapy. After rVV-IL-2 was expanded in VERO cells for 72 h, high titer (108-1010 PFU/ml) rVV-IL-2 were harvested. When 106 murine melanoma cells (F16-F10) were infected with rVV-IL-2, about 200 U/ml IL-2 activity was detected in the supernatants at 8 h, and the up-regulation of ICAM-1 and MHC-I...
Source: Cancer Weekly (1997-05-26)
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