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Cancer Gene Therapy
"Viral Vector-Mediated Transduction of a Modified Platelet Factor 4 cDNA Inhibits Angiogenesis and Tumor Growth."
May 26th, 1997
According to the authors' abstract of an article published in Nature Medicine, "Chronic systemic delivery of therapeutic proteins, such as inhibitors of angiogenesis, present a number of difficult pharmacological challenges. To overcome these problems for one such protein, we constructed retroviral and adenoviral vectors that express a novel, secretable form of the antiangiogenic protein, platelet factor 4 (sPF4). Vector-mediated sPF4 transduction selectively inhibits endothelial cell proliferation in vitro, and results in hypovascular tumors that grow slowly in vivo. Additionally, tumor-associated angiogenesis is inhibited and animal survival is prolonged, following transduction of...
Source: Cancer Weekly (1997-05-26)
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