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Cancer Gene Therapy
"Virus-Mediated Delivery of Antigenic Epitopes into Dendritic Cells as a Means to Induce CTL."
May 26th, 1997
According to the authors' abstract of an article published in Journal of Immunology, "Dendritic cells (DC) are potent inducers of CD8+ T cells and can stimulate protective antitumor immunity when pulsed with an antigenic peptide or protein. We used a replication-deficient adenovirus containing a Kh-restricted antigenic peptide of chicken OVA to study CTL induction in vitro and in vivo after adenovirus-mediated gene transfer into DC. The efficiency of adenovirus-infected DC in eliciting a specific CTL response was compared with immunizations with a recombinant vaccinia virus and DC pulsed with peptide or protein. An immortalized DC line derived from a C57BL/6 mouse and freshly...
Source: Cancer Weekly (1997-05-26)
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