Cancer Gene Therapy
"Virus-Mediated Delivery of Antigenic Epitopes into Dendritic Cells as a Means to Induce CTL."
Published in Cancer Weekly, May 26th, 1997
According to the authors' abstract of an article published in Journal of Immunology, "Dendritic cells (DC) are potent inducers of CD8+ T cells and can stimulate protective antitumor immunity when pulsed with an antigenic peptide or protein. We used a replication-deficient adenovirus containing a Kh-restricted antigenic peptide of chicken OVA to study CTL induction in vitro and in vivo after adenovirus-mediated gene transfer into DC. The efficiency of adenovirus-infected DC in eliciting a specific CTL response was compared with immunizations with a recombinant vaccinia virus and DC pulsed with peptide or protein. An immortalized DC line derived from a C57BL/6 mouse and freshly...
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Source: Cancer Weekly (1997-05-26)
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