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Cancer Vaccines
"Effective Tumor Vaccines Generated by in vitro Modification of Tumor Cells with Cytokines and Bispecific Monoclonal Antibodies."
May 26th, 1997
According to the authors' abstract of an article published in Nature Medicine, "Antitumor immune responses are mediated primarily by T cells. Downregulation of the major histocompatiblity complex (MHC) and the molecules that costimulate the immune response is associated with defective signaling by tumor cells for T-cell activation. In vitro treatment with a combination of cytokines significantly increased the expression of MHC class I and adhesion molecules on tumor cell surfaces. When tumor cells were first incubated with a bispecific monoclonal antibody that binds antigen on tumor cells to CD28 on T cells, the modified tumor cells become immunogenic and are able to stimulate naive T...
Source: Cancer Weekly (1997-05-26)
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