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Kaposi's sarcoma
"Monoclonal Origin of Multicentric Kaposi's sarcoma Lesions."
May 26th, 1997
According to the authors' abstract of an article published in New England Journal of Medicine, "Background: Kaposi's sarcoma has features of both hyperplastic proliferation and neoplastic growth. Multiple lesions, in which spindle cells are prominent, often arise synchronously over widely dispersed areas. We tested the hypothesis that the spindle cells in these multicentric lesions originate from a single clone of precursor cells. Methods: To determine whether Kaposi's sarcoma is a monoclonal disorder, we assessed the methylation patterns of the androgen-receptor gene (HUMARA) in multiple lesions from women with the acquired immunodeficiency syndrome. In polyclonal...
Source: Cancer Weekly (1997-05-26)
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