Cancer Vaccines
"Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by ex vivo Granulocyte-Macrophage Colony-Stimulating Factor Gene Transfer."
Published in Cancer Weekly, June 9th, 1997
According to the authors' abstract of an article published in Cancer Research, "Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced, irradiated tumor vaccines induce potent, T-cell-mediated antitumor immune responses in preclinical models. We report the initial results of a Phase I trial evaluating this strategy for safety and the induction of immune responses in patients with metastatic renal cell carcinoma (RCC). Patients were treated in a randomized, double-blind dose-escalation study with equivalent doses of autologous, irradiated RCC vaccine cells with or without ex vivo human GM-CSF gene transfer. The replication-defective retroviral vector MFG was used for...
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Source: Cancer Weekly (1997-06-09)
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