"Expression of Transgenes in Normal and Neoplastic Anterior Pituitary Cells using Recombinant Adenoviruses: Long Term Expression, Cell Cycle Dependency, and Effects of Hormone Secretion."

According to the authors' abstract of an article published in Endocrinology, "Adenovirus vectors have recently been used to transfer genes into a variety of cell types, including neurons, glial cells, Schwann cells, and epithelial cells. To evaluate the efficiency of gene transfer into pituitary cells using viral vectors, we used replication-deficient recombinant adenovirus vectors (RAds) encoding beta-galactosidase driven by various viral promoters. We tested the ability of RAds to infect and express beta-galactosidase within the different identified cell populations of the anterior pituitary anterior pituitary gland and also in tumor cells of anterior pituitary origin, i.e. GH(3) and...

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