Immunotherapy
"Generation of Tumoricidal Cytotoxic T Lymphocytes from Healthy Donors after in vitro Stimulation with a Replication-Incompetent Vaccinia Virus Encoding MART-1/Melan-A 27-35 Epitope."
Published in Cancer Weekly, June 30th, 1997
According to the authors' abstract of an article published in International Journal of Cancer, "Active specific immunotherapy targeting tumor-associated antigens (TAA) requires reagents of high immunogenicity and safety. To address this issue, we constructed a recombinant vaccinia virus carrying a minigene insert encoding the HLA-A2.1-restricted MART-1/Melan-A(27-35) melanoma TAA (rVV-M). To facilitate the entry of the antigenic epitope into the endoplasmic reticulum, a sequence coding for adenovirus E3/19K leader peptide was added. This rVV-M was made replication-incompetent by treatment with psoralen and UV light. Infection with rVV-M rendered HLA-A2.1 EBV-transformed lymphoblastoid...
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Source: Cancer Weekly (1997-06-30)
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