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Immunotherapy

"Anti-Tumor Effectiveness of Electrochemotherapy with Bleomycin Is Increased by TNF-alpha on SA-1 Tumors in Mice."

Published in Cancer Weekly, July 7th, 1997

According to the authors' abstract of an article published in Cancer Letters, "With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tumor effectiveness on SA-1 tumors was observed after combining TNF-alpha, injected either intratumorally or peritumorally, with electrochemotherapy using suboptimal dose of bleomycin (BLM). The increased anti-tumor effectiveness was neither the result of potentiated anti-tumor effectiveness of TNF-alpha due to exposure of tumors to electric pulses, nor due to interaction with BLM. Therefore, the effect of adjuvant TNF-alpha...

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