Immunotherapy
"Improved Antibody Targeting with Interferon-alpha-2b Conjugate."
Published in Cancer Weekly, July 14th, 1997
According to the authors' abstract of an article published in Journal of Immunotherapy, "This investigation is based on a hypothesis that a biological response modifier, interferon-alpha-2b (IFN), when conjugated with a specific monoclonal antibody (mAb) and given to tumor-bearing animals before the administration of radiolabeled mAb, may not only augment the tumor uptake but may also impede the liver and blood uptake, because the mAb associated with the conjugate may block nonspecific hepatic binding sites and scavenge circulating antigens. ME 31.3 and anti-carcinoembryonic antigen (CEA) F-6 (IgG-2a) specific for human melanoma and colorectal carcinoma, respectively, were chosen as...
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Source: Cancer Weekly (1997-07-14)
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