Conference Coverage (SPIRAT/(NCDDG-HIV)

Antigen-Pulsed Dendritic Cells Enhance Immunity

Published in Cancer Weekly, July 14th, 1997

An immune therapy being explored as a cancer treatment appears applicable to HIV disease.

The therapy calls for dendritic cells, which are potent antigen-presenting cells (APCs), to be pulsed with tumor or HIV antigens and infused into patients to stimulate potent immune responses.

"Both allogeneic and autologous dendritic-cell infusions were well-tolerated and, in patients with CD4⁺ T-cell counts >400 [cells/(mu)L], administration of these antigen-pulsed cells enhanced the immune response to HIV without affecting viral load," concluded Edgar G. Engleman of Stanford University, Palo Alto, California.

Engleman...

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Source: Cancer Weekly (1997-07-14)

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