Cancer Gene Therapy

Liposome-Mediated Therapy for Disseminated Pancreatic Cancer

Published in Cancer Weekly, July 14th, 1997

Liposome-mediated herpes simplex virus thymidine kinase (HSV-tk)/ganciclovir (GCV) suicide-based gene therapy was successful in a murine model of peritoneal dissemination of pancreatic cancer.

Peritoneal dissemination is a common complication of cancers of the digestive tract. Unfortunately, patients who have reached this point often have metastases that are refractory to existing chemo-, radio-, endocrine, and/or immune therapies. Potent therapeutics are desperately needed.

"Gene therapy strategies may provide therapeutic benefits with a more favorable risk-benefit ratio than the current conventional treatments," noted Kazunori Aoki and colleagues...

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Source: Cancer Weekly (1997-07-14)

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