Immunotoxins
"In vivo Efficacy and Toxicity of a Single-Chain Immunotoxin Targeted to CD40."
Published in Cancer Weekly, August 11th, 1997
According to the authors' abstract of an article published in Blood, "G28-5 sFv-PE40 is a single-chain immunotoxin targeted to CD40, which is highly expressed on human hematologic malignancies, including non-Hodgkin's lymphoma, B-lineage leukemias, multiple myeloma, and Hodgkin's disease, as well as certain carcinomas. In vitro analysis showed that this monovalent immunotoxin had a binding affinity of 3 nmol/L, within 15-fold of the bivalent parental monoclonal antibody. G28-5 sFv-PE40 was stable when incubated in mouse serum at 37(degree)C for 6 hours and cleared from the circulation of mice with a half-life of 16.7 minutes. This immunotoxin was effective in treating human Burkitt's...
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Source: Cancer Weekly (1997-08-11)
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