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Plasmodium falciparum

Isolated Plant Compound Shows Activity against Asexual Erythrocytic Stages

Published in Cancer Weekly, August 18th, 1997

A German study showed in vitro antimalarial activity by Betulinic acid against Plasmodium falciparum.

Gerhard Bringmann, Institut fur Organische Chemie der Universitat, Wurzburg, Germany, and colleagues reported that the known lupane-type triterpene betulinic acid (Hegnauer, 1989, Chemotaxonomy of plants, Vol. 8, p. 39-42, Birkhauser Verlag, Basel), isolated for the first time from Triphyophyllum peltatum and Ancistrocladus heyneanus, exhibited "moderate to good in vitro antimalarial activity against asexual erythrocytic stages of the human malaria parasite P. falciparum" ("Betulinic Acid: Isolation from Triphyophyllum peltatum and...

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