Published in Cancer Weekly, September 8th, 1997
Several studies have examined the ability of tumor cells genetically engineered to release cytokines to elicit an immune memory against the parental tumor. However, in most situations, a single cytokine is studied, and very few comparative studies have actually been conducted.
Federica Cavallo and colleagues evaluated the antitumor efficacy of adenocarcinoma cells engineered to release IL-12 in a murine model. Its efficacy was compared with that of other cytokines (IL-4, IL-10,...
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