Cancer Gene Therapy

Antitumor Efficacy of Tumor Cells Engineered to Release Cytokines Compared

Published in Cancer Weekly, September 8th, 1997

Italian researchers compared the antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines with exogenous IL-12 in vivo.

Several studies have examined the ability of tumor cells genetically engineered to release cytokines to elicit an immune memory against the parental tumor. However, in most situations, a single cytokine is studied, and very few comparative studies have actually been conducted.

Federica Cavallo and colleagues evaluated the antitumor efficacy of adenocarcinoma cells engineered to release IL-12 in a murine model. Its efficacy was compared with that of other cytokines (IL-4, IL-10,...

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Source: Cancer Weekly (1997-09-08)

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