Cancer Gene Therapy

Cytokine-Secreting Fibroblasts Serve as a Tumor Vaccine Adjuvant

Published in Cancer Weekly, September 15th, 1997

Syngeneic fibroblasts genetically modified to secrete cytokines act as an adjuvant in a tumor vaccine model of weakly immunogenic cancers.

The local delivery of certain cytokines to the site of a tumor vaccine inoculum results in altered tumorigenicity and up-regulated host immunity to tumor antigens. Most recent approaches have used tumor cells modified to secrete the cytokine. These approaches require an adequate supply of tumor cells which must be supplied either autologously or by a tumor cell line, which is not always feasible in every situation.

In several animal models, a successful alternative approach has been the use of cytokine-secreting...

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Source: Cancer Weekly (1997-09-15)

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