Genetics

Site-Specific Gene Integration Into Human Chromosome 19 Reported

Published in Cancer Weekly, September 29th, 1997

Avigen, Inc., Alameda, California, announced that a protein from a small, non-pathogenic human virus can be used to insert DNA sequences into the human genome in a site-specific manner.

The ability to predictably insert new genetic sequences into a defined location within the human genome has considerable importance for the development of gene therapy applications for cells that divide and give rise to other cells in the body.

Adeno-associated virus (AAV) is a small human virus that has never been associated with any disease. The AAV genome consists of two genes: rep, which controls replication and integration of the virus's DNA, and...

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Source: Cancer Weekly (1997-09-29)

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