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Carcinogenesis (HCV)

Long-Term, Low-Dose IFN May Prevent HCC

Published in Cancer Weekly, September 29th, 1997

Could long-term, low-dose interferon treatment prevent hepatocellular carcinomas in those who are infected with hepatitis C virus'

Researchers in Great Britain suggest that it could.

Nikolai V. Naoumov and colleagues found that persistent hepatitis C virus (HCV) replication is closely associated with hepatocellular carcinoma development in cirrhosis, but that HCV genotypes are not associated with specific malignant transformations.

HCV is an RNA virus with no reverse transcriptase activity and no apparent mechanism for genomic integration. For this reason, it has been assumed that HCV is not directly oncogenic, but rather that...

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