Genetics

KILLER/DR5 Triggers Cancer Cell Death After Chemotherapy Or Radiation

Published in Cancer Weekly, October 6th, 1997

In a significant advance toward understanding the underlying mechanisms responsible for the effectiveness of cancer therapies, investigators at the University of Pennsylvania Medical Center and the Howard Hughes Medical Institute (HHMI) reported identification of a new so-called death-receptor gene called KILLER/DR5 that responds to chemotherapy and radiation by killing cancer cells.

Chemotherapy and radiation have long been among the most powerful clinical weapons available to fight cancer, despite their toxicity. These therapies originally were developed empirically, however, and it is only in recent years that scientists have begun to work out precisely how they are...

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Source: Cancer Weekly (1997-10-06)

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