Immunology

TNF(alpha) Facilitates Immune-Mediated Clearance of Adenoviral Vectors

Published in Cancer Weekly, October 20th, 1997

Increased understanding of the role of tumor necrosis factor (alpha) (TNF(alpha)) in immune-mediated clearance of adenoviral vectors opens avenues for increasing the effectiveness of the vectors in gene therapy studies.

TNF(alpha) is a multifunctional cytokine. In addition to its antitumor effects, it has many proinflammatory properties. Among its actions are the upregulation of adhesion molecules (i.e., intercellular adhesion molecule 1, which recruits leukocytes to the site of inflammation).

Adenoviral (Ad) vectors are extremely efficient for in vivo gene transduction. Unfortunately, there is an equally efficient host immune response against...

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Source: Cancer Weekly (1997-10-20)

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