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Immunology

New Cell Pathway For Triggering Immune System Response Discovered

Published in Cancer Weekly, October 20th, 1997

New cancer treatments could result from the discovery of a pathway in blood cells through which signals triggering the immune system response may be transmitted from the lymphocyte cell surface to its nucleus.

The mechanism was reported in the October 2, 1997, issue of the journal Science.

In making the discovery, researchers at St. Jude Children's Research Hospital located a new protein receptor on the lymphocyte cell surface, identifying it as a member of the important Tumor Necrosis Factor Receptor superfamily, members of which have become targets of a growing number of promising cancer treatments.

Receptors are molecules,...

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