Cancer Gene Therapy (Vaccines)
Cancer Vaccine from IL-18 Transfected Tumor Cells
Published in Cancer Weekly, November 3rd, 1997
IL-18, also know as interferon-gamma-inducing factor (IGIF), is a cytokine which shares similarities with IL-12, e.g., inducing interferon (IFN)-gamma production in Th1 cells. It is a more potent IFN-gamma inducer than IL-12 and could be synergistic with IL-12 to further enhance IFN-gamma production, suggested researchers Long He et al., from the Second Military Medical University, Shanghai, China, and the Japanese Foundation of Cancer Research, Tokyo, Japan.
The researchers constructed a recombinant adenovirus harboring the murine IL-18 gene (AdmIL18) and used the...
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Source: Cancer Weekly (1997-11-03)
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