Published in Cancer Weekly, November 3rd, 1997
Current therapeutic approaches to HCC are limited and rarely result in remission rates above 15-20 percent. Research has shown that the neoplastic transformation hepatocytes undergo is accompanied by a reactivation of fetal programming with the synthesis of hepatoma-associated proteins such as (alpha)-fetoprotein and insulin-like growth factors I and II. IGF-I is associated with cellular growth and differentiation and is expressed in several tumors.
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