Adverse Effects

Study Shows How Chemotherapy Causes Female Infertility

Published in Cancer Weekly, November 10th, 1997

A research team based at the Massachusetts General Hospital (MGH) has discovered, for the first time, the molecular pathways involved in the destruction of oocytes (egg cells) by a common chemotherapy drug.

The discovery eventually could lead to strategies for preserving fertility in girls and women treated with anti-cancer drugs.

In the study in the November 1997 issue of Nature Medicine, the team from the MGH and the Howard Hughes Medical Institute at Washington University School of Medicine in St. Louis, Missouri, described its finding that treatment with the anti-cancer drug doxorubicin (DXR) causes mouse oocytes to undergo apoptosis. ...

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Source: Cancer Weekly (1997-11-10)

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