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Pediatrics (Leukemia)

"Bone Marrow Transplantation Versus Chemotherapy for Maintenance of Second Remission of Childhood Acute Lymphoblastic Leukemia: A Study of the Children's Cancer Group (CCG-1884). DOUBLEQUOT

Published in Cancer Weekly, November 17th, 1997

According to the authors' abstract of an article published in Medical and Pediatric Oncology, "Background: Maintenance of second remission of childhood acute lymphoblastic leukemia (ALL) with intensive chemotherapy is often unsuccessful. The major cause of treatment failure is relapse. Materials and Methods: Of 96 children with ALL who relapsed in the marrow while on or within 1 year of completing initial therapy, 62 achieved a second remission. Nineteen patients underwent bone marrow transplantation in second remission, 11 from a human leukocyte antigen (HLA)-matched related donor, seven using autologous marrow, and one from a matched unrelated donor. The event-free...

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