"Expression of Transforming Growth Factor beta Type III Receptor Suppresses Tumorigenicity of Human Breast Cancer MDA-MB-231 Cells."

According to the authors' abstract of an article published in Journal of Biological Chemistry, "Transforming growth factor beta (TGF-beta) promotes tumor progression in some model systems including human breast cancer cells. In this study, we report that human breast cancer cell lines express reduced amounts of TGF-beta type III receptor (RIII) when compared with untransformed human mammary epithelial cells. Consequently, me examined whether expression of RIII in human breast cancer MDA-MB-231 cells could reduce TGF-beta's tumor promoting activity by sequestering active TGF-beta isoforms produced by the cells. A tetracycline-repressible human RIII expression vector was stably...

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