Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer
"Expression of Transforming Growth Factor beta Type III Receptor Suppresses Tumorigenicity of Human Breast Cancer MDA-MB-231 Cells."
November 24th, 1997
According to the authors' abstract of an article published in Journal of Biological Chemistry, "Transforming growth factor beta (TGF-beta) promotes tumor progression in some model systems including human breast cancer cells. In this study, we report that human breast cancer cell lines express reduced amounts of TGF-beta type III receptor (RIII) when compared with untransformed human mammary epithelial cells. Consequently, me examined whether expression of RIII in human breast cancer MDA-MB-231 cells could reduce TGF-beta's tumor promoting activity by sequestering active TGF-beta isoforms produced by the cells. A tetracycline-repressible human RIII expression vector was stably...
Source: Cancer Weekly (1997-11-24)
|
|
Advertisement |
|
|
