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Breast Cancer
"Translational Research Studies of erbB Oncogenes: Selection Strategies for Breast Cancer Treatment."
November 24th, 1997
According to the authors' abstract of an article published in Cancer Letters, "Specific gene families, e.g, encoding members of signal transduction pathways, show a gene dosage sensitivity. We report on the determination of the gene dosages of egfr and c-erbB-2 in relation to the intratumoral concentration of the tyrosine kinase receptor protein EGFR and p185(c-erbB-2) and the clinical outcome of breast cancer patients in a retrospective study. Prognostic unfavorable subgroups were determined in a life-table analysis by (a) an average gene copy number of egfr of less than 0.4 and greater than 1,6 and an intratumoral EGFR concentration of more than 56 fmol/mg, (b) an intratumoral...
Source: Cancer Weekly (1997-11-24)
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